SP-0512: Translational aspects of particle radiobiology

Physical and Chemical Aspects of Basic Mechanisms in Radiobiology

This little book is the transcribed account of a Highland Park conference on this subject. It was attended by a representative group of persons interested in these basic mechanisms and the discussions were free and informative. The material has been quite well edited and yet has kept the tone of free discussion. This particular volume is somewhat physical and chemical in character and discusses...

Translational aspects of cardiac cell therapy

Cell therapy has been intensely studied for over a decade as a potential treatment for ischaemic heart disease. While initial trials using skeletal myoblasts, bone marrow cells and peripheral blood stem cells showed promise in improving cardiac function, benefits were found to be short-lived likely related to limited survival and engraftment of the delivered cells. The discovery of putative car...

Proton Radiobiology

In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly...

Theoretical Aspects of Particle Production

Radiobiology of Radioresistant Glioblastoma

Therapy of glioblastoma has been very problematic with disappointing results using multiple therapeutic approaches. In general, glioblastomas are considered radioresistant tumors with different radiation modalities failing to control them in the clinic. However a comprehensive and detailed analysis of the radiosensitivity of glioblastoma cells has not been performed. We now present such an anal...